The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...) OBO principles were not originally encoded in a precise fashion, and interpretation was subjective. Here we show how we have addressed this by formally encoding the OBO principles as operational rules and implementing a suite of automated validation checks and a dashboard for objectively evaluating each ontology’s compliance with each principle. This entailed a substantial effort to curate metadata across all ontologies and to coordinate with individual stakeholders. We have applied these checks across the full OBO suite of ontologies, revealing areas where individual ontologies require changes to conform to our principles. Our work demonstrates how a sizable federated community can be organized and evaluated on objective criteria that help improve overall quality and interoperability, which is vital for the sustenance of the OBO project and towards the overall goals of making data FAIR. Competing Interest StatementThe authors have declared no competing interest. (shrink)

In the last decade we witnessed an impressive output of scholarly publications dealing either with issues of Christianization in various parts of the Roman Empire or exploring the interaction of Christianity with pagan religion and local cults. The book by Samellas with its promising title is a welcome addition to these series of works and will interest specialists in religious studies, historians of Late Antiquity and cultural anthropologists alike. The book derives from a dissertation submitted at Yale University in 1999. (...) It is divided into seven chapters that are, in turn, divided into sections; the volume also comprises a short conclusive chapter as well as indices of ancient and modern authors. (shrink)

English summary: In this volume, the Munich and Vienna-based theologian Falk Wagner's work in the fields of philosophical theology, sociology and lived religion is taken up for the first time against the backdrop of current theological and philosophical controversies. The essays integrate Wagner's thinking into the history of theology and philosophy in the twentieth century, reconstruct fundamental elements of his philosophical theology between the poles of speculative theology and lived religion, while also highlighting the constellations and context wherein his theology (...) is situated. The authors explore from a work- and problem-historical perspective the contribution of the systematic theologian to the relevant twenty first century debates. German description: Der vorliegende Band thematisiert erstmals vor dem Hintergrund der gegenwartigen theologischen und philosophischen Kontroversen das Gesamtwerk des Munchener und Wiener Theologen Falk Wagner im Spannungsfeld von philosophischer Theologie, Sozialwissenschaften und gelebter Religion. Die einzelnen Beitrage ordnen dessen Denken in die theologie- und philosophiegeschichtliche Entwicklung des 20. Jahrhunderts ein, rekonstruieren grundlegende Aufbauelemente seiner philosophischen Theologie und beleuchten die Konstellationen, in denen seine Theologie steht. Dabei loten die Autoren sowohl in werkgeschichtlicher als auch in problemgeschichtlicher Perspektive den Beitrag des systematischen Theologen fur die theologischen Debatten im 21. Jahrhundert aus. Mit Beitragen von: Christine Axt-Piscalar, Ulrich Barth, Christian Danz, Wilhelm Grab, Kathrin Mette, Michael Murrmann-Kahl, Jan Rohls, Ewald Stubinger, Folkart Wittekind, Kurt Walter Zeidler, Manuel Zelger. (shrink)

Die Wissenschaftsphilosophie des frühen 20. Jahrhunderts ist reichhaltiger und differenzierter in ihren Standpunkten als lange vermutet. Die Autoren zeigen das anhand der nur teilweise erforschten Interaktion zwischen den Wissenschaftsphilosophen des deutschen und französischen Sprachraums. Das Buch liefert neue Erkenntnisse zur Rolle der Philosophiekongresse in Prag 1934 und Paris 1937 sowie zur Bedeutung einzelner Akteure wie Marcel Boll, der die Rezeption des Logischen Empirismus in Frankreich beförderte. Die Spuren, die Ernst Mach, aber auch der weniger bekannte deutsche Physiologe und Hirnforscher (...) class='Hi'>Ewald Hering in der französischen Wissenschaftsphilosophie hinterliessen, verfolgen die Autoren bis hin zu den Ideen Jean Piagets. Im Mittelpunkt des Buchs stehen Philosophen aus Frankreich, Deutschland und Österreich und ihre Leistung, die Wissenschaften nicht nur erkenntnistheoretisch und logisch durchleuchtet, sondern auch erkannt zu haben, dass ihre theoretische Struktur nur dann vollständig erfasst werden kann, wenn ihre praktische Dimension mit einbezogen wird. Dafür steht Henri Poincaré, der die tragende Rolle der Konventionen für die Theoriebildung in der Mathematik herausstellte. Sichtbar wird der Bezug zur Praxis auch in Moritz Schlicks Überlegungen zu einer auf Empirie basierenden Ethik oder in der Arbeit Otto Neuraths, der eine aus den modernen Wissenschaften gewonnene Konzeption menschlichen Erkennens für das Projekt der gesellschaftlichen Aufklärung fruchtbar machen wollte. (shrink)

This massive two-volume reference presents a comprehensive selection of the most important works on the foundations of mathematics. While the volumes include important forerunners like Berkeley, MacLaurin, and D'Alembert, as well as such followers as Hilbert and Bourbaki, their emphasis is on the mathematical and philosophical developments of the nineteenth century. Besides reproducing reliable English translations of classics works by Bolzano, Riemann, Hamilton, Dedekind, and Poincare, William Ewald also includes selections from Gauss, Cantor, Kronecker, and Zermelo, all translated here (...) for the first time. (shrink)

'Subjetividade e Literatura' tem como ponto de partida o movimento historiográfico do final do século XX. Reúne 16 estudos - e pesquisadores de diferentes áreas do conhecimento - que procuram fundir literatura e história, ou contos e psicanálise, ou ainda arte e romance, objetivando estabelecer uma forma de compreender a realidade culturalmente construída. Esta obra trata da subjetividade, mas também trata de livros, de como eles descrevem - ou interpretam - o que as pessoas percebem e sentem.

This commentary examines Glenberg's characterization of “suppression” in light of negative priming and related phenomena. After offering a radically different slant on suppression, an attempt is made to weave this alternative version into Glenberg's provocative discussion of embodied memories.

This paper presents the case of the post-crisis discursive defence of shadow banking in the Netherlands to argue, first, that there is a need to dust off older elite theories and adapt them to post-democratic conditions where there are no widely shared ‘political formulas’ to secure mass support for elite projects. Second, that temporality should be taken more seriously; it is when stories fail that elite storytelling can be observed in practice. As new ‘political formulas’ are minted and become established, (...) elites can again hope to withdraw from the political scene and leave policy-making to the self-evidence of output legitimacy and/or the perpetuum mobile of There-Is-No-Alternative. This suggests that elite theory should replace an epochal reading of post-democracy with a more conjunctural one. (shrink)

The author offers a conceptual investigation of the tension between openness and protection in well-developed welfare states. Because of a combination of demographic tendencies and labor market shortages, a growing number of European welfare states is currently exploring market-led immigration policies. However, the level of protection these welfare states offer seems hard to reconcile with the low threshold markets that are needed to incorporate newcomers. The author argues that the “solution”lies not so much in a clear political choice for either (...) but rather in the coordinated institutionalization of differentiated citizenship rights. The author illustrates this case with examples taken from the Dutch context, claiming further that the particular combination of corporatist welfare arrangements and the tradition of lenient enforcement in the Netherlands provides a “natural”habitat for the kind of regime pluralism that differentiated citizenship requires. (shrink)

Department of Geography and Planning, University of Amsterdam, The Netherlands There is a growing sense of dissatisfaction among political philosophers with the practical sterility and empirical inadequacy of the discipline. Post-Rawlsian philosophy is wrestling with the need to construct a ‘contextualized morality’ that is sensitive to the particularities and complexities of actual moral reasoning but does not succumb to the temptations of relativism. We argue that this predicament is due to its inability to take the pluralism of our moral universe, (...) the multi-layeredness of our social reality, the indeterminacy of our normative principles and the complexity of our practical reasoning seriously. To incorporate these properties of the ‘human condition’ we have constructed a complex evaluative framework, balancing moral, ethico-political, prudential and realist criteria. We argue that political philosophy new style is well advised to adopt such a framework and to position itself, as a true ‘art’, between political philosophy old style and the social sciences. Thus political philosophy is better equipped to deal with the big tradeoffs of today, rekindle our utopian hopes and regain political bite. Key Words: comparative institutionalism • evaluation studies • political philosophy • political theory. (shrink)

Immanuel Kant's Critique of Pure Reason is widely taken to be the starting point of the modern period of mathematics while David Hilbert was the last great mainstream mathematician to pursue important nineteenth cnetury ideas. This two-volume work provides an overview of this important era of mathematical research through a carefully chosen selection of articles. They provide an insight into the foundations of each of the main branches of mathematics--algebra, geometry, number theory, analysis, logic and set theory--with narratives to show (...) how they are linked. Classic works by Bolzano, Riemann, Hamilton, Dedekind, and Poincare are reproduced in reliable translations and many selections from writers such as Gauss, Cantor, Kronecker and Zermelo are here translated for the first time. The collection is an invaluable source for anyone wishing to gain an understanding of the foundation of modern mathematics. (shrink)

Since the late 1980s, social scientists have argued that advanced economies have undergone a process of financial concentration that is resulting in a growing unevenness of the accessibility of capital. Households, small and medium-sized businesses as well as non-standard economic activities have increasing difficulties in finding funds. There are both sound economic and compelling moral reasons to address this issue. In order to ensure a more equal accessibility of capital, the author proposes a mandatory levy on the surpluses of mainstream (...) pension funds to fund an alternative financial infrastructure as a first step to redressing unevenness. The underlying rationale is that “financial pluralism” is the key to a more even accessibility of capital. (shrink)

The aim of the present study was to investigate the association between work-related moral stress, moral climate and moral sensitivity in mental health nursing. By means of the three scales Hospital Ethical Climate Survey, Moral Sensitivity Questionnaire and Work-Related Moral Stress, 49 participants’ experiences were assessed. The results of linear regression analysis indicated that moral stress was determined to a degree by the work place’s moral climate as well as by two aspects of the mental health staff’s moral sensitivity. The (...) nurses’ experience of ‘moral burden’ or ‘moral support’ increased or decreased their experience of moral stress. Their work-related moral stress was determined by the job-associated moral climate and two aspects of moral sensitivity. Our findings showed an association between three concepts: moral sensitivity, moral climate and moral stress. Despite being a small study, the findings seem relevant for future research leading to theory development and conceptual clarity. We suggest that more attention be given to methodological issues and developing designs that allow for comparative research in other disciplines, as well as in-depth knowledge of moral agency. Copyright © 2011 by SAGE Publications. (shrink)

For researchers who study technology designs, the application and execution of so-called design-oriented research projects are a common way of funding their research. Against this background, we propose a new methodical approach with which VSD can easily be implemented in such projects and which we call “value declaration”. We share our experience with this method which we gained in two design-oriented research projects.

From 802 to 811, we encounter several diplomatic missions beween Byzantium and the Carolingians with the scope to secure or confirm peace, although in 798 such an agreement had been reached. The real target behind such negotiations was a recognition of the coronation and imperial title of Charlemagne since 800, denied by Byzantium for years. It was only in 810 that Nicephorus I yielded due to military/ political difficulties in Northern Italy with Pepin/pippin, son of Charlemagne, and against the Bulgarians. (...) A treaty defined spheres of interest and Byzantine representatives acclaimed Charlemagne as basileus in 812. The present article tries to clarify the different stages and elements of the whole process. When the power of the Carolingian state diminished in the ongoing 9th century, Byzantium step by step deviated from full recognition of the Western emperor, a process clearly visible during the joint venture against Arab Bari from 869 to 871. An appendix deals with the question, if Empress Eirene had offered a kind of junior-emperorship to Charlemagne in 798/799, as already Paul Speck proposed more than forty years ago, without finding much approval. Now it seems probable that he was right. (shrink)

Name der Zeitschrift: Millennium Jahrgang: 11 Heft: 1 Seiten: 237-260.